Colección Digital Complutense


MATERIA PRINCIPAL


MATERIA SECUNDARIA


RESULTADO


Ordenar:

1 registro encontrado (0.00seg).
  • Tumour Cell Lines HT-29 and FaDu Produce Proinflammatory Cytokines and Activate Neutrophils In Vitro: Possible Applications for Neutrophil-Based Antitumour Treatment
    OAI: open archives initiativeTipo de documento: artículoColección E-prints Colección: Archivo institucional e-prints complutense
    • Título de publicación: Mediators of Inflammation
    • Autor: Alcolea, Sonia;Anton, Rosa;Bru, Isabel;Brú Espino, Antonio;Camacho, Mercedes;Porres, Amelia;Remacha, Angel;Soler, Marta;Souto Andres, Joan Carles;Vila, Luis
    • Resumen: There is evidence that polymorphonuclear neutrophils (PMNs) can exert severe antineoplastic effects. Cross-talk between tumour cells and endothelial cells (ECs) is necessary for the accumulation of PMN around a tumour. This work reports the ability of two PMN-sensitive,
    •  
    • human, permanent cell lines-colorectal adenocarcinoma (HT-29) and pharyngeal squamous-cell carcinoma (FaDu) cells-to act as inflammatory foci. PMNs were cytotoxic to both lines, the adhesion of the PMNs to the tumour cells being important in this effect. The tumour cells released appreciable amounts of IL-8 and GRO alpha, and induced the transmigration of PMN through human microvascular-EC monolayers. Conditioning media associated with both lines induced the adhesion of PMN and the surface expression of ICAM-1 in microvascular-EC. In addition, FaDu-conditioning-medium strongly induced the production of proinflammatory cytokines by microvascular-EC. These results support the idea that tumour cells might normally induce a potent acute inflammatory response, leading to their own destruction.
    • Palabras clave: Acute inflammatory response; granulocyte-mediated cytotoxicity; colony-stimulating factor; human-melanoma cells; polymorphonuclear leukocytes; immune-response; nonoxidative mechanisms; endothelial-cells; cancer patients; gro-alpha; cell biology; Immunology
    • Materia: Matemáticas
    • Identificador OAI: oai:www.ucm.es:14832
    • Tipo: Artículo
    • Editorial: HINDAWI PUBLISHING CORPORATION
    • Departamento: Fac. de CC. Matemáticas - Depto. de Matemática Aplicada
    • ISSN: 0962-9351
    • CDU: 616







    [Recurso visitado 14 veces]

    Valoración:  








    Compártelo:
    • Facebook
    • Reporter MSN
    • Menéame
    • Del.icio.us
    • Digg
    • Technorati
    • My Yahoo!
    • Mister Wong
    • Twitter



IMPRIMIR LISTADO


Youtube


Resultados en Youtube


Flickr


Resultados en Flickr

FILTROS:

     COLECCIONES


     RESULTADO EN


     TIPO DE RECURSO


REGISTRO DE USUARIO

| | |
¿Para qué?

MENÚ DE LA SEMANA


OTROS BUSCADORES


TÉRMINOS RELACIONADOS


RED SEMÁNTICA


TE RECOMENDAMOS


NOVEDADES EN CISNE


NOTICIAS RSS DE LA BUC