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  • Tumour Cell Lines HT-29 and FaDu Produce Proinflammatory Cytokines and Activate Neutrophils In Vitro: Possible Applications for Neutrophil-Based Antitumour Treatment
    OAI: open archives initiativeDocument Type: artículoCollection E-prints Collection: Institutional E-print archive complutense
    • Publication Title: Mediators of Inflammation
    • Author: Alcolea, Sonia;Anton, Rosa;Bru, Isabel;Brú Espino, Antonio;Camacho, Mercedes;Porres, Amelia;Remacha, Angel;Soler, Marta;Souto Andres, Joan Carles;Vila, Luis
    • Abstract: There is evidence that polymorphonuclear neutrophils (PMNs) can exert severe antineoplastic effects. Cross-talk between tumour cells and endothelial cells (ECs) is necessary for the accumulation of PMN around a tumour. This work reports the ability of two PMN-sensitive, human, permanent
    •  
    • cell lines-colorectal adenocarcinoma (HT-29) and pharyngeal squamous-cell carcinoma (FaDu) cells-to act as inflammatory foci. PMNs were cytotoxic to both lines, the adhesion of the PMNs to the tumour cells being important in this effect. The tumour cells released appreciable amounts of IL-8 and GRO alpha, and induced the transmigration of PMN through human microvascular-EC monolayers. Conditioning media associated with both lines induced the adhesion of PMN and the surface expression of ICAM-1 in microvascular-EC. In addition, FaDu-conditioning-medium strongly induced the production of proinflammatory cytokines by microvascular-EC. These results support the idea that tumour cells might normally induce a potent acute inflammatory response, leading to their own destruction.
    • Keywords: Acute inflammatory response; granulocyte-mediated cytotoxicity; colony-stimulating factor; human-melanoma cells; polymorphonuclear leukocytes; immune-response; nonoxidative mechanisms; endothelial-cells; cancer patients; gro-alpha; cell biology; Immunology
    • Subject: Matemáticas
    • OAI Identifier: oai:www.ucm.es:14832
    • Type: Artículo
    • Editorial: HINDAWI PUBLISHING CORPORATION
    • Department: Fac. de CC. Matemáticas - Depto. de Matemática Aplicada
    • ISSN: 0962-9351
    • CDU: 616







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  • The semantic component of the evoked potential of differentiation
    OAI: open archives initiativeDocument Type: artículoCollection Revistas UCM Collection: Complutense Portal of scientific journals






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  • Psicoterapia positiva grupal en cáncer. Hacia una atención psicosocial integral del superviviente de cáncer
    OAI: open archives initiativeDocument Type: artículoCollection Revistas UCM Collection: Complutense Portal of scientific journals
    • Main Subject: Educación; Medicina; Psicología
    • Journal: Psicooncología
    • Author: Blanco, Ignacio;Castejón, Vanesa;Gil, Francisco;Maté, Jorge;Ochoa, Cristian;Rodríguez, Ana;Sumalla, Enric C.
    • Number: Vol 7, No 1 (2010)
    • Pages: 7 - 34
    • OAI Identifier: oai:revistas.ucm.es:article/15947
    • Descriptors: Positive psychology ; Positive psychotherapy ; Cancer survivor ; Group psychotherapy ; Positive emotions ; Posttraumatic growth ; Psychosocial adjustment and psychooncology; Psicología positiva ; Psicoterapia positiva
    •  
    • ; Supervivientes cáncer ; Psicoterapia grupal ; Emociones positivas ; Crecimiento postraumático ; Adaptación psicosocial ; Psicooncología
    • Open access date: 01/01/2010
    • Second subject: Psicoterapia







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